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Thiol-benzo-triazolo-quinazolinone covalently modifies Alg44 to inhibit c-di-GMP binding and reduces alginate production by Pseudomonas aeruginosa
Pseudomonas aeruginosa is an opportunistic pathogen that affects a large proportion of cystic fibrosis (CF) patients. CF patients have dehydrated mucus within the airways that leads to the inability of the mucociliary escalator to expel inhaled microbes. Once inhaled, P. aeruginosa can persist in th...
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| Publié dans: | ACS Chem Biol |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6295334/ https://ncbi.nlm.nih.gov/pubmed/29091392 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00826 |
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