X-ray irradiation induced Disabled-2 gene promoter de-methylation enhances radiosensitivity of non-small-cell lung carcinoma cells

BACKGROUND: Disabled-2 (Dab2) is known as a tumor suppressor as well as a Wnt pathway inhibitor. We previously reported that Dab2 was down-regulated due to gene promoter hypermethylation in lung cancer. Here, we aim to study if X-ray irradiation can induce de-methylation of the Dab2 gene and subsequ...

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Библиографические подробности
Опубликовано в: :J Exp Clin Cancer Res
Главные авторы: Ma, Shuang, Zhang, Wan-Lin, Leckey, Bruce D., Xu, Hong-Tao, Yang, Lian-He, Wang, Endi
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2018
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Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295092/
https://ncbi.nlm.nih.gov/pubmed/30547821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-1000-3
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