Precise tracking of vaccine-responding T cell clones reveals convergent and personalized response in identical twins

T cell receptor (TCR) repertoire data contain information about infections that could be used in disease diagnostics and vaccine development, but extracting that information remains a major challenge. Here we developed a statistical framework to detect TCR clone proliferation and contraction from lo...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Pogorelyy, Mikhail V., Minervina, Anastasia A., Touzel, Maximilian Puelma, Sycheva, Anastasiia L., Komech, Ekaterina A., Kovalenko, Elena I., Karganova, Galina G., Egorov, Evgeniy S., Komkov, Alexander Yu., Chudakov, Dmitriy M., Mamedov, Ilgar Z., Mora, Thierry, Walczak, Aleksandra M., Lebedev, Yuri B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Physical Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294963/
https://ncbi.nlm.nih.gov/pubmed/30459272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1809642115
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