Centrosomal protein TRIM43 restricts herpesvirus infection by regulating nuclear lamina integrity

Tripartite motif (TRIM) proteins mediate antiviral host defenses by either directly targeting viral components or modulating innate immune responses. Here we identify a mechanism of antiviral restriction in which a TRIM E3 ligase controls viral replication by regulating the structure of host cell ce...

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Bibliographic Details
Published in:Nat Microbiol
Main Authors: Full, Florian, van Gent, Michiel, Sparrer, Konstantin M.J., Chiang, Cindy, Zurenski, Matthew A., Scherer, Myriam, Brockmeyer, Norbert H., Heinzerling, Lucie, Stürzl, Michael, Korn, Klaus, Stamminger, Thomas, Ensser, Armin, Gack, Michaela U.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294671/
https://ncbi.nlm.nih.gov/pubmed/30420784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-018-0285-5
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