Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes

Insulin gene mutations are a leading cause of neonatal diabetes. They can lead to proinsulin misfolding and its retention in endoplasmic reticulum (ER). This results in increased ER-stress suggested to trigger beta-cell apoptosis. In humans, the mechanisms underlying beta-cell failure remain unclear...

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Publicat a:eLife
Autors principals: Balboa, Diego, Saarimäki-Vire, Jonna, Borshagovski, Daniel, Survila, Mantas, Lindholm, Päivi, Galli, Emilia, Eurola, Solja, Ustinov, Jarkko, Grym, Heli, Huopio, Hanna, Partanen, Juha, Wartiovaara, Kirmo, Otonkoski, Timo
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2018
Matèries:
Stem Cells and Regenerative Medicine
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294552/
https://ncbi.nlm.nih.gov/pubmed/30412052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.38519
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