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VHL Dependent Expression of REDD1 and PDK3 Proteins in Clear-cell Renal Cell Carcinoma

BACKGROUND: Sporadic clear-cell renal cell carcinoma (ccRCC) is associated with mutations in the VHL gene, upregulated mammalian target of rapamycin (mTOR) activity and glycolytic metabolism. Here, we analyze the effect of VHL mutational status on the expression level of mTOR, eIF4E-BP1, AMPK, REDD1...

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Detalhes bibliográficos
Publicado no:J Med Biochem
Main Authors: Ilic, Bojana B, Antic, Jadranka A, Bankovic, Jovana Z, Milicevic, Ivana T, Rodic, Gordana S, Ilic, Dusan S, Tulic, Cane D, Todorovic, Vera N, Damjanovic, Svetozar S
Formato: Artigo
Idioma:Inglês
Publicado em: Sciendo 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294108/
https://ncbi.nlm.nih.gov/pubmed/30581339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1515/jomb-2017-0030
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