Olaparib nanoparticles potentiated radiosensitization effects on lung cancer

BACKGROUND: Poly (ADP-ribose) polymerase (PARP) is a key enzyme in the repair process of DNA strand breaks (DSBs). Olaparib (Ola) is a PARP inhibitor that is involved in arresting PARP release from radiotherapy (RT)-induced damaged DNA to potentiate the effect of RT. Although the underlying mechanis...

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Detalhes bibliográficos
Publicado no:Int J Nanomedicine
Main Authors: Wu, Min, Liu, Jing, Hu, ChuanFei, Li, Dong, Yang, Juan, Wu, ZhouXue, Yang, LingLin, Chen, Yue, Fu, ShaoZhi, Wu, JingBo
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294076/
https://ncbi.nlm.nih.gov/pubmed/30587971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S181546
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