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miR-122 removal in the liver activates imprinted microRNAs and enables more effective microRNA-mediated gene repression

miR-122 is a highly expressed liver microRNA that is activated perinatally and aids in regulating cholesterol metabolism and promoting terminal differentiation of hepatocytes. Disrupting expression of miR-122 can re-activate embryo-expressed adult-silenced genes, ultimately leading to the developmen...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Valdmanis, Paul N., Kim, Hak Kyun, Chu, Kirk, Zhang, Feijie, Xu, Jianpeng, Munding, Elizabeth M., Shen, Jia, Kay, Mark A.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294001/
https://ncbi.nlm.nih.gov/pubmed/30552326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07786-7
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