Attenuation of PKCδ enhances metabolic activity and promotes expansion of blood progenitors

A finely tuned balance of self‐renewal, differentiation, proliferation, and survival governs the pool size and regenerative capacity of blood‐forming hematopoietic stem and progenitor cells (HSPCs). Here, we report that protein kinase C delta (PKCδ) is a critical regulator of adult HSPC number and f...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Rao, Tata Nageswara, Gupta, Manoj K, Softic, Samir, Wang, Leo D, Jang, Young C, Thomou, Thomas, Bezy, Olivier, Kulkarni, Rohit N, Kahn, C Ronald, Wagers, Amy J
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6293338/
https://ncbi.nlm.nih.gov/pubmed/30446598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2018100409
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