The transcription factors TFE3 and TFEB amplify p53 dependent transcriptional programs in response to DNA damage

The transcription factors TFE3 and TFEB cooperate to regulate autophagy induction and lysosome biogenesis in response to starvation. Here we demonstrate that DNA damage activates TFE3 and TFEB in a p53 and mTORC1 dependent manner. RNA-Seq analysis of TFEB/TFE3 double-knockout cells exposed to etopos...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Brady, Owen A, Jeong, Eutteum, Martina, José A, Pirooznia, Mehdi, Tunc, Ilker, Puertollano, Rosa
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2018
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6292694/
https://ncbi.nlm.nih.gov/pubmed/30520728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.40856
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