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The transcription factors TFE3 and TFEB amplify p53 dependent transcriptional programs in response to DNA damage
The transcription factors TFE3 and TFEB cooperate to regulate autophagy induction and lysosome biogenesis in response to starvation. Here we demonstrate that DNA damage activates TFE3 and TFEB in a p53 and mTORC1 dependent manner. RNA-Seq analysis of TFEB/TFE3 double-knockout cells exposed to etopos...
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| Pubblicato in: | eLife |
|---|---|
| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
eLife Sciences Publications, Ltd
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6292694/ https://ncbi.nlm.nih.gov/pubmed/30520728 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.40856 |
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