Propofol Inhibits Cerebellar Parallel Fiber-Purkinje Cell Synaptic Transmission via Activation of Presynaptic GABA(B) Receptors in vitro in Mice

Propofol is a widely used intravenous sedative-hypnotic agent, which causes rapid and reliable loss of consciousness via activation of γ -aminobutyric acid A (GABA(A)) receptors. We previously found that propofol inhibited cerebellar Purkinje cells (PC) activity via both GABA(A) and glycine receptor...

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Pubblicato in:Front Neurosci
Autori principali: Xuan, Fang-Ling, Wang, Hong-Wei, Cao, Li-Xin, Bing, Yan-Hua, Chu, Chun-Ping, Jin, Ri, Qiu, De-Lai
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018
Soggetti:
Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6291502/
https://ncbi.nlm.nih.gov/pubmed/30574067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2018.00922
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