Genomic Analysis of Three Metastatic Prostate Cancer Patients with Exceptional Responses to Carboplatin Indicating Different Types of DNA Repair Deficiency

Platinum-based regimens have not been proved to increase survival from advanced prostate cancer (PCa). Incontrovertible evidence that a proportion of prostate cancers have homologous recombination DNA (HRD) repair defects, and that such genomic aberrations are synthetically lethal with both poly(ADP...

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Publicado no:Eur Urol
Main Authors: Zafeiriou, Zafeiris, Bianchini, Diletta, Chandler, Robert, Rescigno, Pasquale, Yuan, Wei, Carreira, Suzanne, Barrero, Maialen, Petremolo, Antonella, Miranda, Susana, Riisnaes, Ruth, Rodrigues, Daniel Nava, Gurel, Bora, Sumanasuriya, Semini, Paschalis, Alec, Sharp, Adam, Mateo, Joaquin, Tunariu, Nina, Chinnaiyan, Arul M., Pritchard, Colin C., Kelly, Kevin, de Bono, Johann S.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6291437/
https://ncbi.nlm.nih.gov/pubmed/30340782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eururo.2018.09.048
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