The transcription factors GATA2 and MITF regulate Hdc gene expression in mast cells and are required for IgE/mast cell-mediated anaphylaxis

BACKGROUND: Histamine is a critical mediator of IgE/mast cell-mediated anaphylaxis. Histamine is synthesized by decarboxylating the amino acid histidine, a reaction catalyzed by the Hdc-gene encoded enzyme histidine decarboxylase. However, regulation of the Hdc gene in mast cells is poorly understoo...

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Pubblicato in:J Allergy Clin Immunol
Autori principali: Li, Yapeng, Liu, Bing, Harmacek, Laura, Long, Zijie, Liang, Jinyi, Lukin, Kara, Leach, Sonia M., O’Connor, Brian, Gerber, Anthony N., Hagman, James, Roers, Axel, Finkelman, Fred D., Huang, Hua
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6291018/
https://ncbi.nlm.nih.gov/pubmed/29277702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2017.10.043
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