Electrostatic repulsion causes anticooperative DNA binding between tumor suppressor ETS transcription factors and JUN–FOS at composite DNA sites

Many different transcription factors (TFs) regulate gene expression in a combinatorial fashion, often by binding in close proximity to each other on composite cis-regulatory DNA elements. Here, we investigated how ETS TFs bind with the AP1 TFs JUN–FOS at composite DNA-binding sites. DNA-binding abil...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Madison, Bethany J., Clark, Kathleen A., Bhachech, Niraja, Hollenhorst, Peter C., Graves, Barbara J., Currie, Simon L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6290139/
https://ncbi.nlm.nih.gov/pubmed/30315111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003352
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