Nfe2 is dispensable for early but required for adult thrombocyte formation and function in zebrafish

The NFE2 transcription factor is expressed in multiple hematopoietic lineages with a well-defined role in regulating megakaryocyte biogenesis and platelet production in mammals. Mice deficient in NFE2 develop severe thrombocytopenia with lethality resulting from neonatal hemorrhage. Recent data in m...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Rost, Megan S., Shestopalov, Ilya, Liu, Yang, Vo, Andy H., Richter, Catherine E., Emly, Sylvia M., Barrett, Francesca G., Stachura, David L., Holinstat, Michael, Zon, Leonard I., Shavit, Jordan A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Platelets and Thrombopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6290098/
https://ncbi.nlm.nih.gov/pubmed/30504234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018021865
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