Microbiome-Derived Lipopolysaccharide (LPS) Selectively Inhibits Neurofilament Light Chain (NF-L) Gene Expression in Human Neuronal-Glial (HNG) Cells in Primary Culture

The remarkable co-localization of highly pro-inflammatory lipopolysaccharide (LPS) with sporadic Alzheimer’s disease (AD)-affected neuronal nuclei suggests that there may be some novel pathogenic contribution of this heat stable neurotoxin to neuronal activity and neuron-specific gene expression. In...

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Publicat a:Front Neurosci
Autors principals: Lukiw, Walter J., Cong, Lin, Jaber, Vivian, Zhao, Yuhai
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2018
Matèries:
Neuroscience
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6289986/
https://ncbi.nlm.nih.gov/pubmed/30568571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2018.00896
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