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DNA Adducts: formation, biological effects, and new biospecimens for mass spectrometric measurements in humans

Hazardous chemicals in the environment and diet or their electrophilic metabolites can form adducts with genomic DNA, which can lead to mutations and the initiation of cancer. In addition, reactive intermediates can be generated in the body through oxidative stress and damage the genome. The identif...

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Détails bibliographiques
Publié dans:Mass Spectrom Rev
Auteurs principaux: Yun, Byeong Hwa, Guo, Jingshu, Bellamri, Medjda, Turesky, Robert J.
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6289887/
https://ncbi.nlm.nih.gov/pubmed/29889312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mas.21570
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