Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264.7 cells by inhibiting the JNK/NF-κB signaling pathway and activating the PI3K/Akt/Nrf2 pathway

Ulinastatin (UTI) is a broad-spectrum serine protease inhibitor isolated and purified from human urine with strong anti-inflammatory and cytoprotective actions, which is widely used for the treatment of various diseases, such as pancreatitis and sepsis. Although the therapeutic effects of UTI are re...

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Detalhes bibliográficos
Publicado no:Acta Pharmacol Sin
Main Authors: Li, Si-tong, Dai, Qi, Zhang, Shu-xian, Liu, Ya-jun, Yu, Qiu-qiong, Tan, Fei, Lu, Shu-hong, Wang, Quan, Chen, Jian-wen, Huang, He-qing, Liu, Pei-qing, Li, Min
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6289329/
https://ncbi.nlm.nih.gov/pubmed/29323338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2017.143
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