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Antibiotic-Induced Cell Chaining Triggers Pneumococcal Competence by Reshaping Quorum Sensing to Autocrine-Like Signaling

Streptococcus pneumoniae can acquire antibiotic resistance by activation of competence and subsequent DNA uptake. Here, we demonstrate that aztreonam (ATM) and clavulanic acid (CLA) promote competence. We show that both compounds induce cell chain formation by targeting the d,d-carboxypeptidase PBP3...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Domenech, Arnau, Slager, Jelle, Veening, Jan-Willem
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6289044/
https://ncbi.nlm.nih.gov/pubmed/30485808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.11.007
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