Notch Signaling Regulates Mitochondrial Metabolism and NF-κB Activity in Triple-Negative Breast Cancer Cells via IKKα-Dependent Non-canonical Pathways

Triple negative breast cancer (TNBC) patients have high risk of recurrence and metastasis, and current treatment options remain limited. Cancer stem-like cells (CSCs) have been linked to cancer initiation, progression and chemotherapy resistance. Notch signaling is a key pathway regulating TNBC CSC...

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Publicat a:Front Oncol
Autors principals: Hossain, Fokhrul, Sorrentino, Claudia, Ucar, Deniz A., Peng, Yin, Matossian, Margarite, Wyczechowska, Dorota, Crabtree, Judy, Zabaleta, Jovanny, Morello, Silvana, Del Valle, Luis, Burow, Matthew, Collins-Burow, Bridgette, Pannuti, Antonio, Minter, Lisa M., Golde, Todd E., Osborne, Barbara A., Miele, Lucio
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2018
Matèries:
Oncology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6289043/
https://ncbi.nlm.nih.gov/pubmed/30564555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2018.00575
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