Schizophrenia-associated mt-DNA SNPs exhibit highly variable haplogroup affiliation and nuclear ancestry: Bi-genomic dependence raises major concerns for link to disease

Mitochondria play a significant role in human diseases. However, disease associations with mitochondrial DNA (mtDNA) SNPs have proven difficult to replicate. An analysis of eight schizophrenia-associated mtDNA SNPs, in 23,743 Danes without a psychiatric diagnosis and 2,538 schizophrenia patients, re...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Hagen, Christian M., Gonçalves, Vanessa F., Hedley, Paula L., Bybjerg-Grauholm, Jonas, Bækvad-Hansen, Marie, Hansen, Christine S., Kanters, Jørgen K., Nielsen, Jimmi, Mors, Ole, Demur, Alfonso B., Als, Thomas D., Nordentoft, Merete, Børglum, Anders, Mortensen, Preben B., Kennedy, James, Werge, Thomas M., Hougaard, David M., Christiansen, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6287820/
https://ncbi.nlm.nih.gov/pubmed/30532134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0208828
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