Schizophrenia-associated mt-DNA SNPs exhibit highly variable haplogroup affiliation and nuclear ancestry: Bi-genomic dependence raises major concerns for link to disease

Mitochondria play a significant role in human diseases. However, disease associations with mitochondrial DNA (mtDNA) SNPs have proven difficult to replicate. An analysis of eight schizophrenia-associated mtDNA SNPs, in 23,743 Danes without a psychiatric diagnosis and 2,538 schizophrenia patients, re...

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Pubblicato in:PLoS One
Autori principali: Hagen, Christian M., Gonçalves, Vanessa F., Hedley, Paula L., Bybjerg-Grauholm, Jonas, Bækvad-Hansen, Marie, Hansen, Christine S., Kanters, Jørgen K., Nielsen, Jimmi, Mors, Ole, Demur, Alfonso B., Als, Thomas D., Nordentoft, Merete, Børglum, Anders, Mortensen, Preben B., Kennedy, James, Werge, Thomas M., Hougaard, David M., Christiansen, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6287820/
https://ncbi.nlm.nih.gov/pubmed/30532134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0208828
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