A Comparative Study on the Efficacy of NLRP3 Inflammasome Signaling Inhibitors in a Pre-clinical Model of Bowel Inflammation

Nucleotide-binding oligomerization domain leucine rich repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome is pivotal in maintaining intestinal homeostasis and sustaining enteric immune responses in the setting of inflammatory bowel diseases. Drugs acting as NLRP3 blockers could repres...

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Veröffentlicht in:Front Pharmacol
Hauptverfasser: Pellegrini, Carolina, Fornai, Matteo, Colucci, Rocchina, Benvenuti, Laura, D’Antongiovanni, Vanessa, Natale, Gianfranco, Fulceri, Federica, Giorgis, Marta, Marini, Elisabetta, Gastaldi, Simone, Bertinaria, Massimo, Blandizzi, Corrado, Antonioli, Luca
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6287041/
https://ncbi.nlm.nih.gov/pubmed/30559669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01405
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