Overexpression of apelin in Wharton’ jelly mesenchymal stem cell reverses insulin resistance and promotes pancreatic β cell proliferation in type 2 diabetic rats

BACKGROUND: Apelin plays a key beneficial role in energy metabolism by increasing glucose uptake and insulin sensitivity; however, apelin has a short half-life because it is rapidly cleared from the circulation limiting its therapeutic benefit. The aim of this study is to create a new approach to tr...

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Bibliografiske detaljer
Udgivet i:Stem Cell Res Ther
Main Authors: Gao, Lian Ru, Zhang, Ning Kun, Zhang, Yan, Chen, Yu, Wang, Li, Zhu, Ying, Tang, Hai Hong
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6286553/
https://ncbi.nlm.nih.gov/pubmed/30526660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-018-1084-x
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