Dynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fission

Dynamin-related protein 1 (Drp1) is essential for mitochondrial and peroxisomal fission. Recent studies propose that Drp1 does not sever but rather constricts mitochondrial membranes allowing dynamin 2 (Dnm2) to execute final scission. Here, we report that unlike Drp1, Dnm2 is dispensable for peroxi...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Kamerkar, Sukrut C., Kraus, Felix, Sharpe, Alice J., Pucadyil, Thomas J., Ryan, Michael T.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6286342/
https://ncbi.nlm.nih.gov/pubmed/30531964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07543-w
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