Structure-function-guided exploration of the antimicrobial peptide polybia-CP identifies activity determinants and generates synthetic therapeutic candidates

Antimicrobial peptides (AMPs) constitute promising alternatives to classical antibiotics for the treatment of drug-resistant infections, which are a rapidly emerging global health challenge. However, our understanding of the structure-function relationships of AMPs is limited, and we are just beginn...

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Publicat a:Commun Biol
Autors principals: Torres, Marcelo D. T., Pedron, Cibele N., Higashikuni, Yasutomi, Kramer, Robin M., Cardoso, Marlon H., Oshiro, Karen G. N., Franco, Octávio L., Silva Junior, Pedro I., Silva, Fernanda D., Oliveira Junior, Vani X., Lu, Timothy K., de la Fuente-Nunez, Cesar
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6286318/
https://ncbi.nlm.nih.gov/pubmed/30534613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-018-0224-2
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