BRAF Inhibition in BRAF(V600)-Mutant Gliomas: Results From the VE-BASKET Study

PURPOSE: BRAF(V600) mutations are frequently found in several glioma subtypes, including pleomorphic xanthoastrocytoma (PXA) and ganglioglioma and much less commonly in glioblastoma. We sought to determine the activity of vemurafenib, a selective inhibitor of BRAF(V600), in patients with gliomas tha...

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Veröffentlicht in:J Clin Oncol
Hauptverfasser: Kaley, Thomas, Touat, Mehdi, Subbiah, Vivek, Hollebecque, Antoine, Rodon, Jordi, Lockhart, A. Craig, Keedy, Vicki, Bielle, Franck, Hofheinz, Ralf-Dieter, Joly, Florence, Blay, Jean-Yves, Chau, Ian, Puzanov, Igor, Raje, Noopur S., Wolf, Jurgen, DeAngelis, Lisa M., Makrutzki, Martina, Riehl, Todd, Pitcher, Bethany, Baselga, Jose, Hyman, David M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Clinical Oncology 2018
Schlagworte:
Original Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6286161/
https://ncbi.nlm.nih.gov/pubmed/30351999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2018.78.9990
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