Fluconazole induces ROS in Cryptococcus neoformans and contributes to DNA damage in vitro

Pathogenic basidiomycetous yeast, Cryptococcus neoformans, causes fatal meningitis in immunocompromised individuals. Fluconazole (FLC) is a fungistatic drug commonly administered to treat cryptococcosis. Unfortunately, FLC-resistant strains characterized by various degree of chromosomal instability...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Peng, Congyue Annie, Gaertner, Andrea A. E., Henriquez, Sarah Ana, Fang, Diana, Colon-Reyes, Rodney J., Brumaghim, Julia L., Kozubowski, Lukasz
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2018
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6286144/
https://ncbi.nlm.nih.gov/pubmed/30532246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0208471
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