T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition

Programmed cell death–1 (PD-1) is a coinhibitory receptor that suppresses T cell activation and is an important cancer immunotherapy target. Upon activation by its ligand PD-L1, PD-1 is thought to suppress signaling through the T cell receptor (TCR). By titrating PD-1 signaling in a biochemical reco...

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Publicado no:Science
Main Authors: Hui, Enfu, Cheung, Jeanne, Zhu, Jing, Su, Xiaolei, Taylor, Marcus J., Wallweber, Heidi A., Sasmal, Dibyendu K., Huang, Jun, Kim, Jeong M., Mellman, Ira, Vale, Ronald D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6286077/
https://ncbi.nlm.nih.gov/pubmed/28280247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaf1292
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