Progesterone and Nestorone Facilitate Axon Remyelination: A Role for Progesterone Receptors

Enhancing the endogenous capacity of myelin repair is a major therapeutic challenge in demyelinating diseases such as multiple sclerosis. We found that progesterone and the synthetic 19-norprogesterone derivative 16-methylene-17α-acetoxy-19-norpregn-4-ene-3,20-dione (Nestorone) promote the remyelina...

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Bibliographic Details
Published in:Endocrinology
Main Authors: Hussain, Rashad, El-Etr, Martine, Gaci, Ouardia, Rakotomamonjy, Jennifer, Macklin, Wendy B., Kumar, Narender, Sitruk-Ware, Regine, Schumacher, Michael, Ghoumari, Abdel M.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2011
Subjects:
Neuroendocrinology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6285137/
https://ncbi.nlm.nih.gov/pubmed/21828184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2011-1219
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