Limitations of current in vitro models for testing the clinical potential of epigenetic inhibitors for treatment of pediatric ependymoma

BACKGROUND: Epigenetic modifications have been shown to play an important role in the classification and pathogenesis of the pediatric brain tumor ependymoma, suggesting they are a potential therapeutic target. RESULTS: Agents targeting epigenetic modifications inhibited the growth and induced the d...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Rogers, Hazel Anne, Chapman, Rebecca, Kings, Holly, Allard, Julie, Barron-Hastings, Jodie, Pajtler, Kristian W., Sill, Martin, Pfister, Stefan, Grundy, Richard Guy
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2018
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284855/
https://ncbi.nlm.nih.gov/pubmed/30559935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26370
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