Molecular and presymptomatic analysis of a Moroccan Lynch syndrome family revealed a novel frameshift MLH1 germline mutation

Lynch syndrome (LS) is an autosomal dominant disorder characterized by an increased risk of extracolonic cancers and early age of onset. It is associated with germline mutations in the DNA mismatch repair (MMR) genes. We report a case of a patient with colorectal cancer referred to our medical genet...

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Detalhes bibliográficos
Publicado no:Turk J Gastroenterol
Main Authors: Moufid, Fatima Zahra, Bouguenouch, Laila, El Bouchikhi, Ihssane, Houssaini, Mohamed Iraqui, Ouldim, Karim
Formato: Artigo
Idioma:Inglês
Publicado em: Turkish Society of Gastroenterology 2018
Assuntos:
Case Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284679/
https://ncbi.nlm.nih.gov/pubmed/30289396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5152/tjg.2018.17761
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