An integrative study to identify novel scaffolds for sphingosine kinase 1 inhibitors

Sphingosine kinase 1 (SphK1), the enzyme that produces the bioactive sphingolipid metabolite, sphin-gosine-1-phosphate, is a promising new molecular target for therapeutic intervention in cancer and inflammatory diseases. In view of its importance, the main objective of this work was to find new and...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Vettorazzi, Marcela, Angelina, Emilio, Lima, Santiago, Gonec, Tomas, Otevrel, Jan, Marvanova, Pavlina, Padrtova, Tereza, Mokry, Petr, Bobal, Pavel, Acosta, Lina M., Palma, Alirio, Cobo, Justo, Bobalova, Janette, Csollei, Jozef, Malik, Ivan, Alvarez, Sergio, Spiegel, Sarah, Jampilek, Josef, Enriz, Ricardo D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284402/
https://ncbi.nlm.nih.gov/pubmed/28822281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2017.08.017
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