Indoles derived from intestinal microbiota act via type I interferon signaling to limit graft-versus-host disease

The intestinal microbiota in allogeneic bone marrow transplant (allo-BMT) recipients modulates graft-versus-host disease (GVHD), a systemic inflammatory state initiated by donor T cells that leads to colitis, a key determinant of GVHD severity. Indole or indole derivatives produced by tryptophan met...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Swimm, Alyson, Giver, Cynthia R., DeFilipp, Zachariah, Rangaraju, Sravanti, Sharma, Akshay, Ulezko Antonova, Alina, Sonowal, Robert, Capaldo, Christopher, Powell, Domonica, Qayed, Muna, Kalman, Daniel, Waller, Edmund K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284212/
https://ncbi.nlm.nih.gov/pubmed/30257880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-03-838193
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