Grxcr1 Promotes Hair Bundle Development by Destabilizing the Physical Interaction between Harmonin and Sans Usher Syndrome Proteins

Morphogenesis and mechanoelectrical transduction of the hair cell mechanoreceptor depend on the correct assembly of Usher syndrome (USH) proteins into highly organized macromolecular complexes. Defects in these proteins lead to deafness and vestibular areflexia in USH patients. Mutations in a non-US...

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Bibliografiska uppgifter
I publikationen:Cell Rep
Huvudupphovsmän: Blanco-Sánchez, Bernardo, Clément, Aurélie, Fierro, Javier, Stednitz, Sarah, Phillips, Jennifer B., Wegner, Jeremy, Panlilio, Jennifer M., Peirce, Judy L., Washbourne, Philip, Westerfield, Monte
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284068/
https://ncbi.nlm.nih.gov/pubmed/30380418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.10.005
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