Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge

Microglia are yolk sac-derived macrophages residing in the parenchyma of brain and spinal cord, where they interact with neurons and other glial. After different conditioning paradigms and bone marrow (BM) or hematopoietic stem cell (HSC) transplantation, graft-derived cells seed the brain and persi...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Shemer, Anat, Grozovski, Jonathan, Tay, Tuan Leng, Tao, Jenhan, Volaski, Alon, Süß, Patrick, Ardura-Fabregat, Alberto, Gross-Vered, Mor, Kim, Jung-Seok, David, Eyal, Chappell-Maor, Louise, Thielecke, Lars, Glass, Christopher K., Cornils, Kerstin, Prinz, Marco, Jung, Steffen
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284018/
https://ncbi.nlm.nih.gov/pubmed/30523248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07548-5
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