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Red blood cell mechanical sensitivity improves in chronically transfused sickle-cell patients following prolonged, sub-hemolytic shear exposure.

BACKGROUND: Sickle cell disease (SCD) is a genetically-inherited hemoglobinopathy where deoxygenated hemoglobin S polymerizes, leading to stiff red blood cells (RBC) and inefficient microcirculatory blood flow. Transfusion therapy acts as primary and secondary prevention of ischemic stroke in SCD. W...

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Bibliografske podrobnosti
izdano v:Transfusion
Main Authors: Simmonds, Michael J., Suriany, Silvie, Ponce, Derek, Detterich, Jon A.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6283667/
https://ncbi.nlm.nih.gov/pubmed/30325033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/trf.14901
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