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Red blood cell mechanical sensitivity improves in chronically transfused sickle-cell patients following prolonged, sub-hemolytic shear exposure.
BACKGROUND: Sickle cell disease (SCD) is a genetically-inherited hemoglobinopathy where deoxygenated hemoglobin S polymerizes, leading to stiff red blood cells (RBC) and inefficient microcirculatory blood flow. Transfusion therapy acts as primary and secondary prevention of ischemic stroke in SCD. W...
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| Vydáno v: | Transfusion |
|---|---|
| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6283667/ https://ncbi.nlm.nih.gov/pubmed/30325033 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/trf.14901 |
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