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WD40 Repeats Arrange Histone Tails for Spreading of Silencing

Direct binding of WD40 repeat of Embryonic Ectoderm Development (EED) in the Polycomb Repressor Complex 2 (PRC2) to the histone H3 tail regulates the H3K27 methyltrasnferase activity of PRC2. The binding activity is required for the methylation of H3K27 over long distance of a Drosophila chromosome...

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Détails bibliographiques
Publié dans:J Mol Cell Biol
Auteurs principaux: Suganuma, Tamaki, Workman, Jerry L.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6283120/
https://ncbi.nlm.nih.gov/pubmed/20008334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjp046
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