Enzymatic Activity Is Not Required for Phospholipase D Mediated TNF-α Regulation and Myocardial Healing

Phospholipase D1 is a regulator of tumor necrosis factor-α expression and release upon LPS-induced sepsis and following myocardial infarction (MI). Lack of PLD1 leads to a reduced TNF-α mediated inflammatory response and to enhanced infarct size with declined cardiac function 21 days after ischemia...

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Dettagli Bibliografici
Pubblicato in:Front Physiol
Autori principali: Klier, Meike, Gorressen, Simone, Urbahn, Marc-Andre, Barbosa, David, Ouwens, Margriet, Fischer, Jens W., Elvers, Margitta
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018
Soggetti:
Physiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6281985/
https://ncbi.nlm.nih.gov/pubmed/30555342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.01698
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