Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis

Osteoarthritis (OA), a chronic disease characterized by articular cartilage degeneration, is a leading cause of disability and pain worldwide. In OA, chondrocytes in cartilage undergo phenotypic changes and senescence, restricting cartilage regeneration and favouring disease progression. Similar to...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Varela-Eirín, Marta, Varela-Vázquez, Adrián, Guitián-Caamaño, Amanda, Paíno, Carlos Luis, Mato, Virginia, Largo, Raquel, Aasen, Trond, Tabernero, Arantxa, Fonseca, Eduardo, Kandouz, Mustapha, Caeiro, José Ramón, Blanco, Alfonso, Mayán, María D.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6281585/
https://ncbi.nlm.nih.gov/pubmed/30518918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-1225-2
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