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Angiotensin II induces DNA damage via AT1 receptor and NADPH oxidase isoform Nox4
Epidemiological studies revealed increased renal cancer incidences and higher cancer mortalities in hypertensive individuals. Activation of the renin–angiotensin–aldosterone system leads to the formation of reactive oxygen species (ROS). In vitro, in renal cells, and ex vivo, in the isolated perfuse...
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| Publicado no: | Mutagenesis |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6281047/ https://ncbi.nlm.nih.gov/pubmed/22844079 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/mutage/ges033 |
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