Ranking noncanonical 5′ splice site usage by genome-wide RNA-seq analysis and splicing reporter assays

Most human pathogenic mutations in 5′ splice sites affect the canonical GT in positions +1 and +2, leading to noncanonical dinucleotides. On the other hand, noncanonical dinucleotides are observed under physiological conditions in ∼1% of all human 5′ss. It is therefore a challenging task to understa...

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Detalhes bibliográficos
Publicado no:Genome Res
Main Authors: Erkelenz, Steffen, Theiss, Stephan, Kaisers, Wolfgang, Ptok, Johannes, Walotka, Lara, Müller, Lisa, Hillebrand, Frank, Brillen, Anna-Lena, Sladek, Michael, Schaal, Heiner
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6280755/
https://ncbi.nlm.nih.gov/pubmed/30355602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.235861.118
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