EGF/EGFR upregulates and cooperates with Netrin-4 to protect glioblastoma cells from DNA damage-induced senescence

BACKGROUND: Glioblastoma multiforme (GBM) is the most malignant central nervous system tumor. Alkylating agent, temozolomide (TMZ), is currently the first-line chemotherapeutic agent for GBM. However, the sensitivity of GBM cells to TMZ is affected by many factors. And, several clinic trials, includ...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:BMC Cancer
Päätekijät: Li, Li, Huang, Yulun, Gao, Yuge, Shi, Tengfei, Xu, Yunyun, Li, Huini, Hyytiäinen, Marko, Keski-Oja, Jorma, Jiang, Qiuying, Hu, Yizhou, Du, Zhimin
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2018
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6280426/
https://ncbi.nlm.nih.gov/pubmed/30514230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-5056-4
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