Actin stabilizer TAGLN2 potentiates adoptive T cell therapy by boosting the inside-out costimulation via lymphocyte function-associated antigen-1

Correct temporal and spatial control of actin dynamics is essential for the cytotoxic T cell effector function against tumor cells. However, little is known whether actin engineering in tumor-targeted T cells can enhance their antitumor responses, thereby potentiating the adoptive T cell therapy. He...

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Bibliographic Details
Published in:Oncoimmunology
Main Authors: Jeon, Bu-Nam, Kim, Hye-Ran, Chung, Yun Shin, Na, Bo-Ra, Park, Hyunkyung, Hong, Chorong, Fatima, Yasmin, Oh, Hyeonju, Kim, Chang-Hyun, Jun, Chang-Duk
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2018
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6279342/
https://ncbi.nlm.nih.gov/pubmed/30524895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2018.1500674
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