Photoreceptor preservation induced by intravitreal controlled delivery of GDNF and GDNF/melatonin in rhodopsin knockout mice

PURPOSE: To evaluate the potential of a poly(lactic-co-glycolic acid) (PLGA)-based slow release formulation of glial cell line–derived neurotrophic factor (GDNF) alone or in combination with melatonin to rescue photoreceptors in a mouse model of retinal degeneration. METHODS: GDNF and GDNF/melatonin...

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Vydáno v:Mol Vis
Hlavní autoři: García-Caballero, Cristina, Lieppman, Burke, Arranz-Romera, Alicia, Molina-Martínez, Irene. T., Bravo-Osuna, Irene, Young, Michael, Baranov, Petr, Herrero-Vanrell, Rocío
Médium: Artigo
Jazyk:Inglês
Vydáno: Molecular Vision 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6279195/
https://ncbi.nlm.nih.gov/pubmed/30581280
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