Novel Rhodanine Derivative, 5-[4-(4-Fluorophenoxy) phenyl]methylene-3-{4-[3-(4-methylpiperazin-1-yl) propoxy]phenyl}-2-thioxo-4-thiazolidinone dihydrochloride, Induces Apoptosis via Mitochondria Dysfunction and Endoplasmic Reticulum Stress in Human Colon Cancer Cells

We previously reported that 5-[4-(4-fluorophenoxy) phenyl] methylene-3-{4-[3-(4-methylpiperazin-1-yl)propoxy]phenyl}-2-thioxo-4-thiazolidinone dihydrochloride (KSK05104) has potent, selective and metabolically stable IKKβ inhibitory activities. However, the apoptosis-inducing of KSK05104 and its und...

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Veröffentlicht in:Molecules
Hauptverfasser: Jung, Hye-Uk, Lee, Jeong-Hun, Chung, Kyung-Sook, Hong, Joo Young, Choi, Jung-Hye, Kim, Soo-Dong, Roh, Eun Joo, Shin, Kye Jung, Lee, Kyung-Tae
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6278386/
https://ncbi.nlm.nih.gov/pubmed/30404185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23112895
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