Osthole Synergizes With HER2 Inhibitor, Trastuzumab in HER2-Overexpressed N87 Gastric Cancer by Inducing Apoptosis and Inhibition of AKT-MAPK Pathway

Background and Purpose: Although trastuzumab has shown considerable activity in the treatment of HER2-positive breast and gastric cancers, a significant proportion of patients do not respond to trastuzumab. Recent studies revealed that osthole, an active coumarin isolated from Cnidium monnieri (L.)...

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Bibliografiske detaljer
Udgivet i:Front Pharmacol
Main Authors: Yang, Yun, Ren, Feng, Tian, Ziyin, Song, Wei, Cheng, Binfeng, Feng, Zhiwei
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6277458/
https://ncbi.nlm.nih.gov/pubmed/30538636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01392
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