L-Norvaline Reverses Cognitive Decline and Synaptic Loss in a Murine Model of Alzheimer’s Disease

The urea cycle is strongly implicated in the pathogenesis of Alzheimer’s disease (AD). Arginase-I (ARGI) accumulation at sites of amyloid-beta (Aβ) deposition is associated with L-arginine deprivation and neurodegeneration. An interaction between the arginase II (ARGII) and mTOR-ribosomal protein S6...

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Bibliographic Details
Published in:Neurotherapeutics
Main Authors: Polis, Baruh, Srikanth, Kolluru D., Elliott, Evan, Gil-Henn, Hava, Samson, Abraham O.
Format: Artigo
Language:Inglês
Published: Springer International Publishing 2018
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6277292/
https://ncbi.nlm.nih.gov/pubmed/30288668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-018-0669-5
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