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Coexpression of novel furin-resistant LPL variants with lipase maturation factor 1 enhances LPL secretion and activity
LPL is a secreted enzyme that hydrolyzes triglycerides from circulating lipoproteins. Individuals lacking LPL suffer from severe hypertriglyceridemia, a risk factor for acute pancreatitis. One potential treatment is to administer recombinant LPL as a protein therapeutic. However, use of LPL as a pro...
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| Pubblicato in: | J Lipid Res |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The American Society for Biochemistry and Molecular Biology
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6277163/ https://ncbi.nlm.nih.gov/pubmed/30318473 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.D086793 |
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