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Lacosamide at therapeutic concentrations induces histone hyperacetylation in vitro
Inhibition of histone deacetylases (HDACs) and subsequent hyperacetylation of histone proteins lead to altered gene expression associated with therapeutic drug effects, but also with teratogenicity. The only US Food and Drug Administration (FDA)–approved antiepileptic drug that has been consistently...
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| Publicado en: | Epilepsia Open |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
John Wiley and Sons Inc.
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6276773/ https://ncbi.nlm.nih.gov/pubmed/30525123 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/epi4.12269 |
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