Clinical significance of PD-1/PD-Ls gene amplification and overexpression in patients with hepatocellular carcinoma

Background: The remarkable clinical activity of PD-1 antibody in advanced hepatocellular carcinoma (HCC) highlights the importance of PD-1/PD-L1-mediated immune escape as therapeutic target in HCC. However, the frequency and prognostic significance of PD-Ls genetic alterations in HCC remain unknown....

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Publicado en:Theranostics
Autores principales: Ma, Li-Jie, Feng, Fei-Ling, Dong, Liang-Qing, Zhang, Zhao, Duan, Meng, Liu, Long-Zi, Shi, Jie-Yi, Yang, Liu-Xiao, Wang, Zhi-Chao, Zhang, Shu, Ding, Zhen-Bin, Ke, Ai-Wu, Cao, Ya, Zhang, Xiao-Ming, Zhou, Jian, Fan, Jia, Wang, Xiao-Ying, Gao, Qiang
Formato: Artigo
Lenguaje:Inglês
Publicado: Ivyspring International Publisher 2018
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6276293/
https://ncbi.nlm.nih.gov/pubmed/30555574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.28742
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